Basic Research - Infertility & Sexual Dysfunction(구연) International Session (I-008) Geumkang Hall (Avenue 2F) Sep 28(Thu) 15:00-16:00 Could MOTILIPERM improve on acute use of finasteride induced infertility? ¹전북대학교병원, ²경성대학교 약학대학 Keshab Kumar Karna¹, Kiran Kumar Soni¹, Bo Ram Choi¹, Hye Kyung Kim², Yu Seob Shin¹, Jong Kwan Park¹ The aim of the study was to evaluate spermatogenesis injury in rats exposed to finasteride for 56 days and the efficacy of the novel compound MOTILPERM in regulating infertility. Sixty Sprague–Dawley (SD) rats were divided into the following six groups: CTR (control), M 100 (MOTILIPERM 100 mg kg-1), M 200 (MOTILIPERM 200 mg kg-1), F (finasteride 1 mg kg-1), F + M 100 (finasteride 1 mg kg-1 + MOTILIPERM 100 mg kg-1) and F + M 200 (finasteride 1 mg kg-1 + MOTILIPERM 200 mg kg-1). The rats were treated orally with 100 and 200 mg kg-1 MOTILPERM alone or in combination with finasteride 1 mg kg-1 once daily for 56 days. There were no significant effect on body weight, testis weight, epididymis weight, testicular or epididymal sperm counts and sperm motility. Johnsen score and spermatogenic cell density were significantly improved in MOTILIPERM treated group compared to finasteride group (p < 0.05). Testicular MDA level was deceased in MOTILIPERM treated group compared to finasteride treated group. Serum testosterone and DHT level were increased significantly in MOTILIPERM treated group (p < 0.05). Endoplasmic reticulum (ER) stress and apoptotic activity were not significant in finasteride group compared to control. However, improvement had been observed in MOTILIPERM treated group. These results showed that finasteride group displayed no significant effect in spermatogenesis. Moreover, the present finding support MOTILIPERM may improve hormonal imbalance and prevent ER stress in testis. keywords : Finasteride,infertility, MOTILIPERM