Basic Research - Cancer(구연) (NP-006) Association of FOXP3 expression and related signaling pathway with prognosis in human prostate cancer 서울의료원 비뇨기과¹, 경희대학교 의과대학 비뇨기과학교실² 최승권¹, 최태수², 이상협², 유구한², 이동기², 민경은², 전승현², 이선주², 이형래², 장성구² Purpose: FOXP3 is a transcription factor and well-known hallmark of immune suppressive T regulatory cells (Tregs). Recent studies reported that FOXP3 plays an important role in tumor development. Thus, we investigated tumoral FOXP3, infiltrated Tregs count, NF-κB, Lats2, and YAP expression in prostate cancer, and the relationships between expression of these proteins and clinicopathological variables. Materials and Methods: We evaluated 46 prostate cancer patients who underwent radical prostatectomy at our institute from 2006 to 2013. We analyzed immunohistochemistry of tissues, in relation to survival and other clinicopathological factors. Results: Positive tumoral FOXP3 expression was significantly related with worse pathologic stage and Gleason score (GS), positive surgical margin, and higher tumor volume (positive vs. negative; pT3 52.2% vs. 15%; pGS 8-10 26.1% vs. 15%; positive margin 39.1% vs. 15%; tumor volume 70.1% vs. 67.7%). Patients with NF-κB expression were showed similar trend to FOXP3 expression gourp (high vs. low expression; pT3 60% vs. 27.3%; pGS 8-10 50% vs. 12.1%; tumor volume 42% vs. 20%). Furthermore, patients with positive FOXP3, and NF-κB experienced biochemical recurrence compared to those with negative groups. Conclusions: These findings suggested that FOXP3 and NF-κB expression is associated with unfavorable clinicopathological variables in prostate cancer. In conclusion, the high expression of FOXP3 in prostate cancer cells is thought to contribute to tumorigenesis and progression of prostate cancer. keywords : FOXP3, prostate cancer, prognosis