Infertility & Sexual Dysfunction(구연) (NP-055) 증등도 이상의 하부요로증상을 호소하는 60세 이상 남성 환자에서 발기부전의 잠재적 위험인자로서 감소된 혈중 vitamin D level ¹동국대학교 의과대학 비뇨기과학교실,²서울대학교 의과대학 비뇨기과학교실² 김형석¹,윤현식¹,김재홍¹,이해원¹,이정우¹,배정범¹,조민철² Objective: To evaluate the impact of serum 25-hydroxyvitamin D [25(OH)D] level on erectile dysfunction (ED) in male patients complaining lower urinary tract symptoms (LUTS). Methods: We analyzed the data on 534 male patients who were evaluated for LUTS from 2014 to 2017. LUTS severity was classified into mild (≤7) or moderate to severe (≥8) based on the total sum of International Prostate Symptom Score (IPSS). Vitamin D deficiency was defined as serum 25(OH)D level of less than 20 ng/ml. The severity of ED was dichotomized into tolerable (no or mild ED: ≥ 17 points) or intolerable (moderate to severe ED: ≤ 16 points) depending on International Index of Erectile Function-5 scores. The impact of serum 25(OH)D level on intolerable ED was assessed using univariable and/or multivariable logistic regression analyses. Results: In the entire cohort, intolerable ED was significantly associated with age ≥ 60 years (hazard ratio [HR], 1.762, 95% confidence interval [CI], 1.011-3.073) and moderate to severe LUTS (HR, 2.075, 95% CI, 1.134-3.789), but not with serum 25(OH)D level (HR, 1.004, 95% CI, 0.979-1.23). Whereas, in subgroup (n=223) consisting of moderate to severe LUTS patients above 60 years old, either increasing serum 25(OH)D level (HR, 0.944, 95% CI, 0.903-0.986) or vitamin D deficiency (HR, 2.949, 95% CI, 1.118-7.782) was the independent risk factor of intolerable ED as a result of each multivariable analysis. Conclusion: Our results imply low vitamin D level may contribute to the occurrence of intolerable ED in the elderly moderate to severe LUTS patients. Therefo keywords : Lower urinary tract symptoms,erectile dysfunction,vitamin D