Infertility & Sexual Dysfunction(구연) Oral Session 2 / Infertility & Sexual Dysfunction (O-019) Crystal A (3F) 11월28일(수) 13:00-14:00 발기장애에 있어 나이트릭 옥사이드 관련 물질의 잠재적 역활에 대한 체계적 고찰 및 메타분석 건국대학교병원 비뇨의학과, 건국대학교 의학전문대학원 김아람, 박영진, 최우석, 박형근, 김형곤, 백성현 Purpose: To assess the potential role of nitric oxide (NO) producing supplements on erectile dysfunction as alternatives to PDEi. Material and Methods: Studies published up to April 2018 that evaluated the efficacy of NO producing agents were identified from multiple databases studies comparing NO-producing supplements with placebo or untreated, focusing only on patients with mild to moderate severity of erectile dysfunction, and presenting outcomes such as improvement rate, IIEF score, and testosterone level were included. Results: In total, 20 articles (15 RCTs and 5 non-RCTs) met inclusion criteria reporting outcomes of 1206 erectile dysfunction (ED) patients. Analysis demonstrated significant improvement on ED with NO-producing supplements compared to placebo or untreated (OR: 8.54 [3.59, 20.32], P<0.00001, I2=70). NO-producing supplements also induced significant improvement on IIEF5(OR: 3.02 [0.55, 5.50], P=0.02, I2=79%) and IIEF15 scores (OR: 3.09 [0.52, 5.65], P=0.02, I2=33%). IEFF subdomains of overall satisfaction, sexual desire, and erectile function were significantly changed, but intercourse satisfaction, orgasmic function, and testosterone level remain unchanged. Conclusion: Existing evidence supports the benefit of NO-producing supplements as alternatives or mutual complement to PDEi in mild to moderate ED patients. NO-producing supplements may be safer and psychologically more accepted than PDEi.Along with improving erectile dysfunction, NO-producing supplements may also contribute to increase in sexual desire, which may not be enhanced by PDEi. keywords : Nitric Oxide pathway-related supplements, erectile dysfunction