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급성전립선염 환자에서 저용량 타달라필 및 탐수로신 병용치료의 효과에 대한 초기연구 |
| 차의과학대학교 의과대학 비뇨의학과교실, 분당차병원 |
| 유영동, 김태현, 최경화, 이승렬, 박동수, 홍영권* |
Objective: To evaluate the effect low dose tadalafil and tamsulosin combination therapy on acute prostatitis treatment regarding therapeutic efficacy and safety.
Methods: A total of 56 acute prostatitis patients who were hospitalized to two urologic clinics (21 patients: clinic 1, 35 patients: clinic 2) were randomly divided into two therapeutic groups: group 1 received intravenous ceftriaxone 2g and oral tamsulosin 0.2mg, group 2 received additional daily low dose tadalafil 5mg to ceftriaxone and tamsulosin. Both groups underwent the survey of questionnaires regarding pain, lower urinary tract symptom and erectile function by using the numerical rating scale (NRS), the international prostate symptom score (IPSS) and the international index of erectile function (IIEF-5), respectively. Tamsulosin and tadalafil were applied to both groups for more than 2 weeks
Results: Both groups were assigned with 28 patients each. Most commonly used antibiotics in both groups was 2g of intravenous ceftriaxone/day (50.0% vs. 57.1%). Between two groups, no significant differences were observed regarding in terms of Age, BMI, hospitalization duration, prostate volume, and types of antibiotics used. Both groups showed similar initial total IIEF-5 scores, and total IPSS scores. However, group 2 showed significantly greater improvements in terms of total IIEF-5 scores, and total IPSS scores after 7 days of treatment (p=0.042 and p=0.025, respectively). No significant PSA difference was observed between two groups before and after treatment.
Conclusions: Low dose tadalfil and tamsulosin combination therapy is effective for improving potency and urinary symptoms in acute prostatitis patients. |
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keywords : acute prostatitis, tadalafil, potency |
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