Cancer - Prostate(구연) Oral Session 1 / Cancer - Prostate (Ⅰ) (O-004) Grand Ballroom(2F) 11월28일(수) 13:00-14:00 전립선암 환자에게 안드로겐 박탈 치료와 인지기능장애와의 관계: 심평원 빅데이터를 이용한 연구 고려대학교 의과대학 안산병원 비뇨의학과 태범식, 전병조, 최훈, 배재현, 박재영 목적: To evaluate the association of androgen deprivation therapy (ADT) with cognitive dysfunction. 대상및방법: Using the National Health Insurance Service database of the entire Korean adult prostate cancer population (n=236,391), data on ADT and cognitive dysfunction between 2008 and 2015 were analyzed. We excluded patients previously diagnosed with cognitive dysfunction, dementia, or a cerebral event history. We tested the effect of ADT on the risk of cognitive dysfunction using propensity score–matched Cox proportional hazards regression models and Kaplan-Meier survival analysis. Our final cohort comprised of 35,401 individuals with prostate cancer, including 24,567 men (70.6%) who underwent ADT. 결과: During a mean follow-up period of 4.1 years, 4,741 patients were newly diagnosed with cognitive dysfunction. A statistically significant association was found between ADT and the risk of cognitive dysfunction (hazard ratio [HR] 1.169, p=0.002). Meanwhile, age (≥70 years), diabetes, hypertension, cardiovascular history, and peripheral vascular disease were identified as factors that contribute to the increased risk of cognitive dysfunction. Kaplan–Meier analysis demonstrated that patients aged 70 years or older who underwent ADT had the lowest cumulative probability of remaining cognitive dysfunction-free (log-rank p<0.001). 결론:Our results revealed an association between the use of ADT for the treatment of prostate cancer and an increased risk of cognitive dysfunction in a nationwide population-based study. keywords : Prostate neoplasm, Androgen deprivation therapy, Cognitive dysfunction, Nationwide population-based study