Cancer - Prostate(구연) (NP-038) 호르몬 박탈요법을 받은 전립선암 환자에서 간략한 위험성 평가 모델: the Korean Cancer Study-prostate risk classification 울산대학교 의과대학 비뇨기과학교실 최세영, 임범진, 한재현, 경윤수, 안동현, 김휘우, 이원철, 채한규, 이재훈, 최원석, 유달산, 홍준혁, 안한종, 김청수 Objective: To investigate progression to castration-resistant prostate cancer (CRPC) after primary androgen deprivation therapy (ADT), and to build a simple risk prediction model for primary ADT patients based on the Japan Cancer of the Prostate Risk Assessment (J-CAPRA) criteria. Methods: Six-hundred and two patients who received primary ADT were entered into the Korean Cancer Study of the Prostate (KCS-prostate) database. The effect of prognostic factors was determined by multivariate analysis. For each patient, the weight of all factors was totaled to give a KCS-prostate score; patients were divided into 3 risk groups according to their score. The probability of CRPC, cancer-specific survival (CSS) and overall survival (OS) was estimated by Kaplan-Meier analysis. Results: On multivariate analysis for CRPC, the significant variables were initial PSA (>40ng/mL; 1 point), biopsy Gleason score (≧9; 1 point), clinical N1 (1 point) nonregional lymph node (1 point), bone (1 point), or visceral metastasis (1 point). KCS-prostate scoring model was calculated with a score of 0 to 6 (0; low, 1-2; intermediate, ≧3; high risk). The risk groups stratified CRPC (p < 0.0001), CSS (p < 0.0001), and OS (p < 0.0001) on Kaplan-Meier graph. KCS-prostate model predicted CRPC with a c-index of 0.7242, CSS with a c-index of 0.7036, and OS with a c-index of 0.5890. Five-year estimated CRPC/cancer specific death rates were 10.3%/6.3% of low, 48.4%/22.2% of intermediate, and 81.7%/53.1% of high risk. Conclusions: The KCS-prostate risk classification, modified J-CAPRA, is a simple scoring model for predicting oncologic outcomes after primary ADT. keywords : Androgen deprivation therapy, Prognosis, Risk classification