Cancer - Prostate(구연) Oral Session 1 / Cancer - Prostate (Ⅰ) (O-007) Grand Ballroom(2F) 11월28일(수) 13:00-14:00 성 호르몬 수치와 전립선암과의 관계 울산대학교 의과대학 비뇨기과학교실 최세영, 임범진, 한재현, 경윤수, 안동현, 김휘우, 이원철, 채한규, 이재훈, 최원석, 유달산, 정인갑, 김청수 Objectives: The aim of this study was to evaluate the association of sex hormones with prostate cancer. Materials and methods: Data from 415 patients who had diagnosed as prostate cancer and had serum sex hormone labs were used. Sex hormone labs included total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). We reviewed the condition of prostate cancer including clinical TNM stage and biopsy factors. Changes of serum hormone levels after the usage of ADT and after the withdrawal of ADT were evaluated. In the sub-group of androgen deprivation therapy (ADT)-unexposed cohort with history of radical prostatectomy (n=225), pathologic characteristics were collected. Multiple linear regression analysis for tumor volume and logistic regression analysis to predict adverse pathology were used. Adverse pathology was defined as ≥ Grade Group 3, ≥ pathologic T3b, or pathologic N1. Results: In total cohort, 129 (31.1%) of pre-treatment, 175 (42.2%) of post-operation, 32 (7.7%) of biochemical recurrence, 59 (14.2%) of during ADT, and 20 (4.8%) of castration-resistant prostate cancer were observed at the first lab exam. Baseline serum levels of SHBG, LH, FSH and testosterone were not different among pre-treatment, post-operation and biochemical recurrence (p>0.05). LH, FSH, and testosterone significantly decreased after 3 months of ADT start, and increased after 3 months of ADT withdrawal. SHBG were maintained regardless of ADT start or withdrawal. On multivariate analysis, SHBG level was significantly associated with tumor volume of pathology (beta: -0.11, 95% confidence interval [CI]: -0.20–-0.02, p=0.021). On multivariate logistic analysis, LH level (odds ratio [OR]: 1.28, 95% CI: 1.03–1.59, p=0.029), initial prostate-specific antigen level (OR: 1.05, 95% CI: 1.00–1.10, p=0.043), Grade Group 4/5 (vs 1; OR: 21.95, 95% CI: 6.49–74.25, p<0.001), and clinical T stage ≥3 (vs 2; OR: 4.75, 95% CI: 1.96–11.52, p<0.001) were significant predictors for adverse pathology. Conclusion: LH, FSH, and testosterone were affected by the ADT. In the ADT-unexposed cohort, low SHBG level was associated with high tumor volume and high LH level was associated with adverse pathology. Endocrine axis may paly important roles in prostate cancer progression. keywords : testosterone, sex hormone-binding globulin, luteinizing hormone