Cancer - Kidney(구연) (NP-021)

T1 stage 국소 신장암이면서 70세 이상 환자에서의 신장암 수술 방법이 생존율에 미치는 영향 분석
서울아산병원 울산대학교 의과대학 비뇨기과학교실, ¹건강의학과교실
경윤수¹, 최세영, 임범진, 유달산, 정인갑, 송채린, 홍범식, 홍준혁, 안한종, 김청수
Objective: Compared between the nephron sparing option represented by partial nephrectomy (PN) and the commonly lower surgical morbidity option represented by radical nephrectomy (RN) in elderly patients with limited life expectancy.

Methods: We retrospectively reviewed 109 patients aged >70 years who underwent RN (n = 59) or PN (n = 50) for clinical T1 stage renal mass between January 2006 and December 2012. Clinicopathologic data were thoroughly analyzed and compared between the RN and PN groups. Overall survival was assessed by the Kaplan-Meier survival analysis and the Cox proportional hazards regression model.

Results: During a median follow-up period of 85.6 months, total 23 cases of death events were founded (15 cases in RN group and 8 cases in PN group). Patients who underwent RN were older (74.8 ± 3.6 vs. 73.4 ± 2.1 years, p=0.01) with larger tumors (4.4 ± 1.3 vs. 2.4 ± 0.9 cm, p<0.01) than patients treated with PN. The mean follow-up duration was no significant difference between two group (84.7 ± 27.1 vs. 86.7 ± 25.1 months, p=0.69). The 10 years overall survival rate did not differ between the RN and PN groups (59.9% vs. 68.0% p = 0.234). According to the multivariable analysis, type of nephrectomy remained independent predictors of overall survival (HR 0.249, p = 0.01)

Conclusions: In overall mortality, PN is more effective than RN in over 70 years old with localized T1 stage renal mass management.
keywords : aged, nephrectomy, mortality

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