Cancer - Prostate(구연) Oral Session 1 / Cancer - Prostate (Ⅰ) (O-008) Grand Ballroom(2F) 11월28일(수) 13:00-14:00 Parathyroid hormone is associated with prostate cancer in Asian population 충북대학교 의과대학 비뇨기과학교실 김원태, 이희윤, 서성필, 강호원, 김용준, 윤석중, 이상철, 김원재 Background: The present study investigated the association of serum parathyroid hormone (PTH), vitamin D, and calcium levels with prostate cancer (CaP), especially in an Asian population. Methods: The study population consisted of an experimental group [459 patients including 216 CaP and 243 benign prostate hyperplasia (BPH)] and a prostatectomy group (47 radical prostatectomy patients). Patients with serum creatinine levels >1.4 mg/dl, parathyroid disease, and/or PTH levels <10 pg/ml were excluded. CaP and BPH patients were compared, and the correlation between serum parameters and clinical data was determined. Preoperative and postoperative PTH levels were compared in the prostatectomy group. Results: Mean PTH levels were 41.67 ± 28.82 and 27.06 ± 17.32 pg/ml in the CaP and BPH groups, respectively (p<0.001). When patients were divided into two groups according to prostate-specific antigen levels (<50 or ≥50 ng/ml), Gleason score (≤7 or ≥8), and stage (≤T3 or ≥T4), there was no significant difference in PTH levels between the two groups. Mean postoperative PTH levels (26.93 ± 13.58 pg/ml) were significantly lower than preoperative PTH levels (36.71 ± 21.04 pg/ml) in the same radical prostatectomy patients. Conclusions: Serum PTH levels were higher in CaP than in BPH patients, and decreased significantly after radical prostatectomy. The present results suggest an association between serum PTH and CaP. Further large cohort studies are necessary to validate the present data. keywords : prostatic neoplasms, parathyroid hormone, calcium