Infertility & Sexual Dysfunction(구연) Oral Session 2 / Infertility & Sexual Dysfunction (O-012) Crystal A (3F) 11월28일(수) 13:00-14:00 Effects of daily tadalafil 5mg administration on post micturition dribbling (PMD) in men with lower urinary tract symptoms: A Prospective, Multicenter, Double-blind, Randomized Clinical study 1 한림대학교 강동성심병원 비뇨의학과, 2 춘천성심병원 비뇨의학과, 3 동탄성심병원 비뇨의학과 정현철¹, 고경태¹, 김성용¹, 이원기², 이성호³, 양대열¹ Introduction Although post-micturition dribbling (PMD) is a very uncomfortable symptom of lower urinary tract symptoms (LUTS) but it tends to be underestimated in the clinical field. As part of senile change, decreased volume of penile corpus cavernosum and associated dilation of the bulbous urethra occurs, these are thought to be associated with symptoms of PMD. So we investigated the effect of daily dosing of 5 mg tadalafil on PMD. Materials and methods From Nov 2017 to Aug 2018, patients aged 20 to 70 years with IPSS score of 8 or higher and had PMD symptoms were included. In total, 102 patients were enrolled from 3 hospitals participated in this study. Eligible patients were randomly assigned to the tadalafil 5mg group or tadalafil placebo group. Primary endpoint was the changes in PMD symptoms that were evaluated through the “Hallym Post Micturition Dribbling Questionnaire (HPMDQ),” which was designed for this study. IPSS, IIEF, PEDT, PEP, IELT questionnaire were compared among groups at 4 and 12 weeks. Results There were no differences in the baseline characteristics among 2 groups. After 12 weeks of treatment, HPMDQ score was improved to 3.5 ± 1.4 compared to 5.7 ± 2.3 for initial score in the tadalafil group (p<0.05). In the placebo group, initial HPMDQ score was 5.2 ± 2.6 and after 12 weeks of treatment, score was improved to 4.1 ± 2.3. Compared with the reduction of HPMDQ by 2 points or more, there was a significant difference of 71% in the tadalafil group and 18% in the placebo group (p<0.001). Tadalafil group also significantly improved the EF domain score compared to placebo group (p<0.01), but in the IPSS score, there was no significant difference between 2 groups (p>0.05). No patients experienced any serious adverse effects in any of groups. Conclusions We investigated the effects of tadalafil 5mg on PMD in men. Daily administration of tadalafil 5mg seems to be one of the breakthrough options in the treatment of PMD. keywords : post-micturition dribbling, tadalafil, HPMDQ