Incontinence & Female Urology & Neurourology(구연) (NP-049) 궤양성 방광통증증후군/간질성방광염 환자에서 방광요관역류의 유병율 및 위험인자 순천향대학교 의과대학 비뇨의학과교실 김웅빈, 이상욱, 이광우, 김준모, 김영호, 김민의 Purpose The purpose of this study is to investigate the incidence and risk factors associated with vesicoureteral reflux (VUR) in patients with ulcerative bladder pain syndrome/Interstitial Cystitis (BPS/IC). Material and Methods We evaluated 211 patients with BPS/IC who underwent cystoscopy and confirmed the presence of Hunner’s ulcer from May 2011 to July 2017 retrospectively. Among these patients, 113 patients whose functional bladder capacity was 300cc or less according to the voiding diary were included in this study. All patients were evaluated by voiding cystourethrography (VCUG) to check for the presence of bladder destruction and VUR. Patients were classified into two groups according to presence of VUR and the risk factors for VUR include the locations and numbers of Hunner’s ulcer, functional bladder capacity, maximal flow rate (Qmax), post voiding residual urine volume (PVR), the degrees and duration of the pain were assessed using univariate and multivariate logistic regression analysis. Results Of 113 patients, the mean bladder capacity was 205.3±77.9cc and 28 patients were confirmed VUR by VCUG (28/113, 24.8%). The maximum functional bladder capacity of patients with VUR was significant lower than patients without VUR (156.8±72.8cc vs. 221.2±73.2cc, p<0.05) and it affects the presence of VUR in univariate analysis. In addition to functional bladder capacity, the location of Hunner’s ulcer especially in peri-ureteral location was also significant risk factor whereas other parameters such as numbers of ulcer, degrees of pain, duration of symptoms, Qmax and PVR did not affect the presence of VUR in ulcerative BPS/IC. In multivariate logistic regression analysis, the peri-ureterally location of Hunner’s ulcer was the only independent risk factor for presence of VUR in ulcerative BPS/IC (OR, 3.506; 95% CI, 2.380 to 5.164; p<0.001) (Fig. 1). Conclusions The incidence of VUR in patients with ulcerative BPS/IC is relatively high and the urologist has to consider the presence of VUR in the management of the patients with ulcerative BPS/IC especially when confirmed peri-uretrally located Hunner’s ulcer. keywords : interstitial cystitis, bladder pain syndrome, vesicoureteral reflux