Cancer - Prostate(구연) Oral Session 1 / Cancer - Prostate (Ⅰ) (O-010) Grand Ballroom(2F) 11월28일(수) 13:00-14:00 비전이성 전립선암 환자에서 근치적 전립선 절제술과 호르몬 치료의 생존률 비교 1가톨릭대학교 서울성모병원 비뇨의학과, 2 가톨릭대학교 부천성모병원 비뇨의학과, 3한국보건의료연구원, 4이화여자대학교 융합보건학과, 5서울대학교병원 비뇨의학과, 6서울아산병원 비뇨의학과, 7분당서울대병원 비뇨의학과, 8삼성서울병원 비뇨의학과, 9가톨릭대학교 성빈센트병원 비뇨의학과, 10연세대학교 비뇨의학과, 11가톨릭대학교 암연구소 하유신1,11, 최진봉2, 심정임3, 강민주3, 박은정3, 강신희3, 박주연3, 양정임3, 최인순3, 안정훈4, 곽철5, 정창욱5, 김청수6, 변석수7, 서성일8, 이현무8, 이승주9, 이승환10, 정병하10, 이지열1,3,11 Background: We conducted a comparative survival analysis between primary androgen deprivation therapy (PADT) and radical prostatectomy (RP) based on nationwide Korean population data including all patients with prostate cancer. Materials and Methods: A total of 4,538 prostate cancer patients from the National Health Insurance Service (NHIS) database linked with Korean Central Cancer Registry data (KCCR) who were treated with primary PADT or RP between January 1 2007 and December 31 2014 were enrolled. Kaplan–Meier (KM) and multivariate survival analyses stratified by stage (localized and locally advanced) and age (<75 and ≥75) were performed using a Cox proportional-hazards model to evaluate the treatment effect. Results: Of 18,403 patients from the NHIS database diagnosed with prostate cancer during the study period, 4,538 who met the inclusion criteria were included in the analysis. Of these, 3,136 underwent RP and 1,402 received PADT. There was a significantly increased risk of death in patients who received PADT compared with those who underwent RP in the propensity score matched (PSM) cohort. In subgroup analysis stratified by stage and age, patients who received PADT had a significantly increased risk of death compared with patients who underwent RP in every subgroup. Especially, a much greater risk was observed in those with locally advanced prostate cancer. Conclusion: In a nationwide survival analysis of non-metastatic prostate cancer, we found that RP provided a survival benefit compared PADT. The current study provides valuable evidence regarding the decision of treatment method in Asian prostate cancer patients. keywords : prostate cancer, androgen deprivation therapy, prostatectomy