Cancer - Bladder, Pelvis, Ureter & Others(구연) (NP-015) 당뇨병 환자에서 비근육침윤성방광암의 재발 및 진행에 대한 혈당 조절의 영향 전남대학교 의과대학 비뇨기과학교실 김명수, 유성현, 정세헌, 정호석, 유호송, 황의창, 김선옥, 오경진, 정승일, 강택원, 권동득, 박광성 Purpose: To investigate the relationship between glycemic control and non-muscle invasive bladder cancer. Materials and Methods: From January 2004 to May 2015, 617 patients with non-muscle-invasive bladder cancer were analyzed (group 1: patients without DM, n = 499; group 2: DM with preoperative Hb A1c < 7, n = 58; DM with preoperative Hb A1c ≥ 7, n = 60). An 1:2 propensity-score matching was performed using variables related to tumor progression, such as age, sex, BMI, tumor multiplicity, size, grade, pathologic stage. Results: There was no significant difference in tumor characteristics between group 1 and group 2. The tumor recurrence of group 2 was higher than group1, but not statistically significant, and tumor progression was similar (33.0% vs 44.8%, p=0.074, 11.4% vs. 12.0%, p=0.888). Group 3 had significantly higher tumor multiplicity, pathologic stage than Group 1 (multiplicity >3, 42.4% vs. 58.3%, p=0.02 ; pathologic stage > T1, 30.9% vs. 43.3%, 0.039). The tumor recurrence and progression of Group 3 were higher than group 1 (33% vs. 48.3%. p=0.019; 11.4% vs. 31.6%, p<0.001). After propensity score matching between Group 1 and Group 3, there was no significant difference in the characteristics of tumor (multiplicity >3, 59.2% vs. 58.3%, p=0.02 ; pathologic stage > T1, 45.8% vs. 43.3%, 0.717) and recurrence rate (41.7% vs. 48.3%, p=0.428). But, the tumor progression of Group 3 was significantly higher than group 1 (15.8% vs. 31.6%, p=0.02). Kaplan–Meier analysis showed significant differences in progression-free survivals between Group 1 and Group 3 (p = 0.023). Conclusion: Poor glycemic control was related to the shorter progression-free survival of patients with non-muscle invasive bladder cancer. keywords : Bladder Cancer, Progression, Diabetes Mellitus