Endourology & Stone Disease(구연) Oral Session 6 / Endourology & Stone Disease (Ⅰ) (O-056) Crystal A (3F) 11월28일(수) 14:00-15:00 경피적 신절석술에서 예방적 항생제 1 회 투여와 3일 투여요법의 세균 감염 예방 효과에 대한 비교: 무작위 배정 연구 울산대학교 의과대학 비뇨기과학교실 채한규, 신정현, 박형근 Objectives : To determine the proper regimen of antibiotic prophylaxis for the prevention of bacterial infections in patients who are receiving percutaneous nephrolithotomy (PCNL). Materials and Methods : Forty patients who planned to undergo PCNL from October 2015 to August 2017 were randomly assigned into two groups. Patients in the single-dose group (n=20) were administered an intravenous single dose of 2g ceftriaxone 30 minutes before PCNL, whereas those in the three-days regimen group (n=20) were administered a preoperative intravenous single dose of 2g ceftriaxone and additional postoperative oral cefpodoxime proxetil (100mg twice a day) for three days. Incidences of infectious complications such as pyrexia, systemic inflammatory response syndrome (SIRS), and sepsis were compared between the two groups. Results : Fever (axillary temperature >38.0◦ C) did not develop in any of the patients in the single-dose group but developed in one patient (5.0%) in the three-days regimen group due to pneumonia (p=0.33). SIRS developed in a total of 8 patients (20.0%), four patients from each group. None of the patients in either group developed sepsis after PCNL. Conclusions : The three-days prophylactic antibiotic regimen did not demonstrate better efficacy for the prevention of bacterial infections in patients with PCNL compared to the single-dose prophylactic antibiotic regimen. keywords : Percutaneous nephrolithotomy, prophylactic antibiotics