Cancer - Prostate(구연) (NP-037) 전립선암 환자에서 수술전 측정한 PSA를 통한 병리학적 T stage의 예측 ¹연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소 ²조선대학교 의과대학 비뇨기과학교실 김민석¹,임동훈²,장원식¹,고동훈¹,고혁준¹,이종수¹,정두용¹,오경택¹,최영득¹ Background: Patients diagnosed with prostate cancer after prostate biopsy want to know about their cancer stage when they visit outpatient clinic. However, PSA and Gleason score alone are not easy to mention the cancer stage. So we performed a study to predict the pathologic stage with preoperative PSA. Methods: From January 2006 to February 2017, 4732 patients with prostate cancer who underwent radical prostatectomy at Yonsei University Severance Hospital were retrospectively analyzed. We included 3925 patients except for patients with anti-androgen or 5-alpha reductase inhibitor administration and distant metastasis. We analyzed preoperative PSA and pathologic T stage by using Receiver Operation Characteristic Curve. Of the 3925 patients, T2a and T2b group was 557, T2c group was 1191, T3a group was 1535, T3b group was 601 and T4 group was 41. Results: The areas under the curves (AUC) for T2c, T3a, T3b and T4 were 56.7%, 62.7%, 78.6% and 90.8% (Fig 1). PSA cut off value was obtained only for groups with AUC greater than 70%. PSA cut off value of T3b group was 11.3, sensitivity was 70.7% and specificity was 70.8%. PSA cut off value of T4 group was 18.7, sensitivity was 82.9% and specificity was 82.7%. Conclusion: In our study, PSA did not correlate with pathologic stage at T2 and T3a group. But it was fair to predict T3b with PSA and excellent to predict T4 with PSA. According to the prior studies, we can see that the 5 year survival rate is lower at T4 and the biochemical recurrence rate is higher at T3b. In conclusion, this study suggests that preoperative PSA may be helpful in predicting the pathologic T stage (T3b or T4) and prognosis of patient with prostate cancer after prostate biopsy. keywords : Prostate cancer, PSA, Stage