Cancer - Bladder, Pelvis, Ureter & Others(구연) MP Session Ⅱ (MP-012) Geumkang Hall (Avenue 2F) 11월 28일(수) 17:00-18:00 상부요로 이행세포암에 대하여 근치적 신장요관 절제술과 부분 요관 절제술의 종양학적 및 기능적 비교 성균관대학교 의과대학 비뇨기과학교실 이충언, 나준필, 강민용, 전황균, 정병창, 서성일, 전성수, 이현무, 성현환 Introduction: Recently, nephron sparing surgery in upper tract urothelial carcinoma (UTUC) is becoming an issue. So, in this study, we compare oncologic and functional outcomes between radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in UTUC. Materials and Methods: We retrospectively analyzed records of 394 patients treated with RNU from 2008 to 2016 and 38 patients treated with SU from 2009 to February 2018. Progression free survival (PFS), cancer specific survival (CSS), overall survival (OS), upper tract cancer recurrence free survival, bladder cancer recurrence free survival and eGFR preservation rate after operation were examined. Results: Patient characteristics are shown at Table 1. Difference of PFS (p = 0.469), CSS (p = 0.711), OS (p = 0.119) and bladder cancer recurrence free survival (p=0.924) between RNU and SU were not statistically significant. (Figure 1.) And, in the multivariate regression model for progression, SU is not associated with the progression after UTUC surgery. However, in upper tract cancer recurrence, SU shows more chance to recur than RNU. (98.1% vs 92.2% at 3-year follow up, p = 0.001) (Figuire 1.) In terms of renal function, eGFR preservation rate after 1 year of operation, SU was superior to RNU. (78.3±24.6 % vs 109.2±29.8 %, p < 0.001) Conclusion: RNU and SU showed no signficant difference in PFS, CSS, OS and bladder cancer recurrence. But upper tract recurrence is more common in SU. In terms of renal functional outcome, SU shows superior results in preservation of renal function. keywords : Radical nephroureterectomy, Segmental ureterectomy, Oncologic and functional outcome