Infertility & Sexual Dysfunction(구연) Oral Session 2 / Infertility & Sexual Dysfunction (O-013) Crystal A (3F) 11월28일(수) 13:00-14:00 슈도에페드린 치료 불응성 역행성 사정에서 부스피론의 효과 고려대학교 의과대학 비뇨기과학 교실 안순태, 이동현, 정형국, 김상우, 김제종, 문두건 Objective The treatment of retrograde ejaculation (RE) is important not only for fertility but also for satisfaction of sexual intercourse. Ideally, the goal of treatment is to establish antegrade ejaculation, not only for the sperm retrieval. The use of sympathomimetics for the treatment of RE is well-known, however the overall success rate does not exceed 50%. The aim of the present study is to evaluate the efficacy of buspirone (non-benzodiazepine anxiolytics) in neurogenic RE. Material and methods The complete RE patients who were refractory to previous pseudoephedrine treatment included in the study. RE was diagnosed in patients who complained absence of ejaculated after orgasm and identified sperm in a post-ejaculatory urine sample. The patients who were taking alpha-adrenergic blocker and psychotropic medication, and who were taken the bladder neck or transurethral resection of the prostate, were excluded in this study. All patients were given buspirone 5mg twice/day for 4 weeks. We evaluated the efficacy of buspirone by the establishment of antegrade ejaculate after 4 weeks of treatment. Results Total 26 patients were diagnosed with complete RE refractory to pseudoephedrine. 5 of 26 were excluded due to previous history of bladder neck surgery and psychotropic medication. The most common etiologies were diabetes mellitus (42.9%) and idiopathic (28.6%). Other etiologies were identified as follows: spinal cord injury (19.0%), parkinson’s disease (4.8%) and multiple sclerosis (4.8%). Twelve of 21 patients (57.1%) were achieved antegrade ejaculation. One patient discontinued the study due to adverse events (developing dizziness) and one patient had mild dyspepsia; the remaining patients had no adverse drug-related events. Conclusion In patients with neurogenic RE, buspirone was effective for inducing antegrade ejaculation in more than 50% of patients. We suggest that if the first line treatments such as pseudoephedrine or imipramine are not effective, buspirone may be warranted. keywords : retrograde ejaculation, buspirone, pseudoephedrine