Infertility & Sexual Dysfunction(구연) (NP-053) 전립선 비대증 및 발기 부전 환자의 tamsulosin 0.4mg/tadalafil 5mg 복합제의 복용도와 초기 복용 중단 이유 고려대학교 의과대학 비뇨기과학교실 안순태, 이동현, 정형국, 김상우, 김종욱, 김제종, 문두건 Introduction Recent study has demonstrated the greater efficacy of with fixed-dose combination of tamsulosin 0.4mg/tadalafil 5mg (FDC 0.4/5 mg) compared to tadalafil 5mg mono-therapy in patients with benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). Single tablet administration is expected to improve compliance of drug but the adherence to FDC 0.4/5 mg has never been investigated. This study was aim to assess the compliance of and the reasons for early discontinuation of FDC 0.4/5 mg. Material Methods From August 2017, FDC 0.4/5 mg was prescribed in a total of 102 patients, with BPH-associated lower urinary symptoms and ED. We assessed adherence until 6 month and the reasons for early discontinuation during initial 6 month. The cumulative discontinuation rate was assessed using a Kaplan–Meier analysis. Results Of the 102 patients, 57 were a first-time for coadministration of a-blockers and phosphodiesterase type 5(PDE5) inhibitors as FDC 0.4/5 mg and 45 were switched to FDC 0.4/5 mg. Mean follow up duration was 4.8 ± 1.7 months and mean FDC 0.4/5 mg administration duration was 3.5 ± 2.0 months. Until 6 months, an increasing cumulative discontinuation rate was observed in months 1, 3, and 6 (25.5%, 40.9%, and 53.0%, respectively). The 6 months adherence were statistically significantly greater in switched group than in naive group (Log-rank test: p<0.037). (Figure 1.) The reasons for discontinuation were in order of side effects (52.1%), inconvenience of daily usage (16.7%), perceived poor efficacy (14.6%), seeking for other treatment options (8.3%), cost (2.1%) and unknown (8.3%). Conclusion The patient with switched from coadministation of a-blocker and PDE5 inhibitors to FDC 0.4/5 mg showed greater adherence than patients with initial treatment as FDC 0.4/5 mg. The main reason for discontinuation was the side effects and also lack of efficacy and the inconvenience of daily usage were frequently reported causes. keywords : tamsulosin, tadalafil, fixed-dose combination