Cancer - Prostate(구연) (NP-032) 전이 전립선암에서 거세저항성 전립선암으로 진행하는 기간에 영향을 미치는 인자 울산대학교 의과대학, 서울아산병원 비뇨기과 임범진, 최세영, 경윤수, 안동현, 김휘우, 이원철, 채한규, 이재훈, 최원석, 유달산, 송채린 정인갑, 홍범식, 홍준혁, 안한종, 김청수 Objective: In the present study, we reassessed the factors affecting duration to castration resistant prostate cancer from metastatic hormone-sensitive prostate cancer. Methods: A total of 154 patients who have metastatic lesion at the time of diagnosis of prostate cancer and underwent androgen deprivation therapy (ADT) were retrospectively analyzed. In this retrospective cohort, we analyzed the clinicopathologic factor on affecting duration to castration resistant prostate cancer from metastatic hormone-sensitive prostate cancer using the Kaplan-Meier method and Cox proportional hazard model. Median follow-up duration was 29 months Results: The median age of patients was 70 years and median initial prostate-specific antigen (PSA) level was 557ng/ml. The Gleason score was 6 or 7 in 17 patients (11.0%), 8 in 55 (35.7%), and 9 or 10 in 82 (53.2%). We assessed regional node metastasis and visceral metastasis at the diagnosis in 102 patients (66.2%) and 18 (11.7%). In multivariate analysis, PSA ≥20 (hazard ratio 2.845 95% confidence interval 1.227-6.597) and biopsy gleason score ≥8 (hazard ratio 1.955 95% confidence interval 1.296-2.951) were independent predictors of resistant castration. Conclusions: High PSA and high gleason score were independent predictors of castration resistant prostate cancer in metastatic hormone-sensitive prostate cancer keywords : Prostate Cancer, metastatic hormone-sensitive prostate cancer, castration resistant prostate cancer