Cancer - Prostate(구연) Oral Session 1 / Cancer - Prostate (Ⅰ) (O-003) Grand Ballroom(2F) 11월28일(수) 13:00-14:00 전립선암 환자에서 생식선자극호르몬 분비호르몬길항제의 사용이 심혈관질환과 당뇨병에 미치는 영향: 전국을 대상으로한 코호트 연구 한림대학교 의과대학 비뇨의학과교실¹,성균관대학교 의과대학 비뇨의학과교실²,울산대학교 의과대학 비뇨의학과교실³,한림대학교 의과대학 작업환경의학과교실⁴ 심명선¹,방우진¹,오철영¹,이용성¹,전성수²,안한종³,주영수⁴.조진선¹ Introduction: To investigate whether androgen deprivation therapy (ADT) with gonadotropin-releasing hormone agonist (GnRHa) in prostate cancer (Pca) patients is associated with cardiovascular disease and diabetes mellitus (DM) in the cohort based from the entire Korean population. Materials and Methods: Using the Korean national health insurance database, we conducted an observational study of 579,377 men who sought treatment due to Pca between January 1, 2012 and December 31, 2016. After excluding patients with previously diagnosed cardiovascular disease, DM and Chemotherapy, we extracted data of 2,053 patients who started GnRHa (GnRHa use) and 2,654 men who were newly diagnosed as Pca (Nonuse) from July 1, 2012 to December 31, 2012, with follow-up through to December 31, 2016. Primary outcomes were development of cerebrovascular attack (CVA), ischemic heart disease (IHD), acute myocardial infarction (MI), and DM. Results: GnRHa Users were older, reside more in the rural area, had lower socioeconomic status and had more comorbidities than Nonusers (all p<0.0500). Although GnRHa Users demonstrated an increased incidence of only CVA (p=0.0134) in the univariate analysis, GnRHa use was not associated with an increased risk of CVA, IHD, MI, and DM while age at diagnosis was strongly associated with all 4 diseases in the multivariate analysis. The cumulative duration of ADT was also not associated with the outcomes. Conclusion: Our complete enumeration for Korean Pca population suggest that ADT was not associated with and increased risk of caridiovascular disease and DM. Differences in patient characteristics should be carefully considered for the analysis in this subject. keywords : androgen deprivation therapy, prostate cancer, cardiovascular disease, diabetes