Cancer - Kidney(구연) Oral Session 5 / Cancer - Kidney (Ⅰ) (O-041) Grand Ballroom(2F) 11월28일(수) 14:00-15:00 신세포암에서 예후인자로서의 Glasgow Prognostic Score의 가치: 진단검사정확도 메타분석 ¹분당제생병원 비뇨기과학교실, ²아주대학교 의과대학 비뇨기과학교실 조대성¹, 김세중², 김선일² Purpose: The objective of this study was to perform a meta-analysis of the diagnostic test accuracy of Glasgow Prognostic Score (GPS) as a prognostic factor for renal cell carcinoma (RCC). Materials and Methods: Studies were retrieved from PubMed, Cochrane, and EMBASE databases and we performed comprehensive searches to identify studies that evaluated the prognostic impact of pretreatment GPS in RCC patients. We assessed sensitivity, specificity, summary receiver operating characteristic curve (SROC) and area under curve (AUC). Results: Totally, studies were searched under the pre-specified criteria and 8 studies with a total of 1,191 patients were included to evaluate the prognostic impact of GPS in RCC finally. They indicated a pooled sensitivity of 0.785 (0.705-0.848), specificity of 0.782 (0.656-0.871), diagnostic odds ratio (DOR) of 13.089 (7.168-23.899) and AUC of 0.83 (0.79-0.86). Heterogeneity was significant and meta-regression revealed that presence of metastasis was might be the potential source of heterogeneity. Subgroup analysis also demonstrated that presence of metastasis might be the source of heterogeneity. Conclusions: GPS demonstrated a good diagnostic accuracy as a prognostic factor for RCC and especially in case of non-metastatic RCC. keywords : Renal cell carcinoma, Glasgow Prognostic Score, Diagnostic test accuracy