Endourology & Stone Disease(구연) (NP-046) 요로 결석 성분과 대사성 요인들의 연관성에 관한 연구 고려대학교 의과대학 비뇨기과학교실 김재윤, 태종현, 윤성구, 진현중, 심지성, 노태일, 강석호, 천준, 이정구, 김제종, 강성구 We aimed to investigate the effects of factors related to metabolic disease on urinary stone composition. We analyzed 583 patients with information on urinary stone composition among 1034 patients who underwent surgical intervention between March 2014 and May 2017. We classified the patients into uric acid stone formers (UA) and non-uric acid stone formers (non UA) according to presence of uric acid component. We compared age, sex, height between UA and non UA formers. And we compared the underlying disease including metabolic disease such as DM, hyperlipidemia, hypertension and serum analysis results including glucose, glycosylated hemoglobin level (HbA1c) which reflect metabolic status between two groups. Uric acid stone formers were 147 (25.2%) and non-uric acid stone former were 436 (74.8%). The mean age was higher in UA group (64.82±12.53 vs 56.33±13.80; P<0.001). On chi square analysis, patients in the UA group had a higher proportion of diabetes (28.6% vs 17.2%; P =0.003) and hypertension (50.3% vs 40.4%; P =0.035), and coronary artery disease (CAD) (12.2% vs 6.4%; P =0.024). And patients in the UA group had higher mean serum HbA1c level (6.61±1.28 vs 6.18±1.19; P=0.004) and glucose level (132.9±71.13 vs 117.9±38.31; P=0.018). On multivariate regression analysis, age and HbA1c was statistically significant (P=0.001, 0.011, respectively). Age and HbA1c is a risk factor for urolithiasis, particularly uric acid stones in our study. It is anticipated that diabetic patients will have a preventive effect of uric acid stones through thorough blood glucose management. keywords : metabolic disease, stone analysis, metabolic stone