Cancer - Prostate(구연) (NP-065) 항남성호르몬 박탈요법을 시행받는 전립선암 환자에서 체계적 운동요법 교육과 주기적인 환자교육 피드백이 치료 합병증 개선에 미치는 영향: Actigraph accelerometer를 이용한 연구 ¹성균관대학교 스포츠과학과 ²연세대학교 의과대학 비뇨의학교실 박생렬¹, 김진우², 안현규², 김종원², 민규랑², 정병하², 구교철² Purpose: Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is associated with reduced physical function and quality of life (QoL). We investigated the impact of a structured lifestyle intervention program on promoting physical activity (PA) and reducing sedentary behavior (SB), and its effect on QoL in men with PCa on long-term ADT. Methods: This randomized controlled study included 22 patients with advanced PCa on ADT. Patients were randomized to an intervention (n = 11) or a control (n = 11) group between February 2018 and May 2019. The intervention group received a structured lifestyle intervention from sports medicine specialists to promote moderate-to-vigorous PA and to reduce SB. Text messages containing educational and motivational contents were delivered 3 times weekly. Following screening (0 month), the trial involved two supervision visits (1 and 2 months) and 1 maintenance visit (3 months). At each visit, accelerometers were used to assess PA and SB, and questionnaires to measure QoL, life satisfaction, anxiety, and depression. Results: Baseline EORTC QLQ-C30 and HADS scores, sedentary behavior, moderate-to-vigorous PA, clinicopathological features related to PCa, body mass index, Charlson comorbidity index, and performance status were comparable between the two arms. At maintenance visit (M), compared to baseline (B), a significantly greater improvement in QoL was observed in the intervention arm (B = 10.20, M = 10.60) compared to the control arm (B = 7.25, M = 6.50); p = 0.020, Cohen’s d = 1.865. For depression, there was a significantly greater reduction in the intervention arm (B = 7.80, M = 4.80) compared to the control arm (B = 11.25, M = 10.50); p = 0.044, Cohen’s d = 1.53. There were no significant improvements in anxiety, sedentary behavior, or moderate-to-vigorous PA. Conclusions: A lifestyle intervention program should be offered whenever indicated to patients on ADT for its inherent advantage in improving QoL and reducing depression. keywords : lifestyle, prostatic neoplasm, quality of life