Cancer - Prostate(구연) (NP-036) 한국인에서의 가족력과 임상적으로 의미 있는 전립선암 진단과의 연관성 분석 ¹연세대학교 의과대학 비뇨의학교실 박지수¹, 구교철¹, 한웅규¹, 홍창희¹, 나군호¹, 최영득¹, 정병하¹, 이광석¹ Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen (PSA) level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio (OR) = 2.99 (1.330-6.704), p = 0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR = 6.32 (2.790-14.298), p < 0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history. keywords : Prostate cancer; Family history; Biopsy