Cancer - Prostate(구연) (NP-063) 임상/병리학적 특징에 기반하여 근치적 전립선 절제술을 시행한 환자에서의 생존율 구분 ¹연세대학교 의과대학 비뇨의학교실 박지수¹, 구교철¹, 한웅규¹, 홍창희¹, 나군호¹, 최영득¹, 정병하¹, 이광석¹ Background: When making clinical decisions concerning additional treatment for patients who have undergone radical prostatectomy (RP), adverse laboratory/pathological features are considered major factors. We investigated and compared the prognostic efficacy of adverse laboratory/pathological features in predicting overall survival (OS) and biochemical failure (BCF) in these patients. Methods: The Korean Prostate Cancer Database was used to identify patients undergoing RP between May 2001 and April 2013. Patients with incomplete clinicopathological data or positive lymphadenectomy results were excluded. Finally, 4,486 patients included in the final analysis were categorized based on their adverse laboratory/pathological features. Results: Adverse pathological features and detectable prostate-specific antigen (PSA) levels 6 weeks after surgery were observed in 1,977 (44.1%) and 634 (14.1%) patients, respectively. PSA levels, pathological Gleason score ≥8, adverse pathological features [positive surgical margin (PSM), seminal vesicle invasion (SVI), and extracapsular extension (ECE)], and adverse laboratory features (detectable PSA levels after 6 weeks) together were significant predictors of BCF-free survival (BCFFS). SVI was identified as a predictor of OS. Additionally, patients with ECE, PSM, and detectable PSA levels after 6 weeks, but without SVI, showed similar OS to those without ECE, PSM, and detectable PSA levels after 6 weeks and with SVI (log-rank test, P = .976). Conclusions: We successfully stratified patients based on adverse laboratory/pathological features after RP and demonstrated that these are important prognostic factors for OS and BCFFS. Additionally, we identified the criteria for selecting appropriate patients for undergoing additional treatment based on OS and BCFFS. keywords : Prostatectomy, Risk assessment, Survival