Cancer - Prostate(구연) (NP-062) Subclassification of pathologically organ-confined (pT2) prostate cancer does not significantly predict postoperative outcomes in Korean men 창원경상대학교병원¹, 분당서울대학교병원² 이민호¹, 이상철², 홍성규², 변석수², 이상은² Objectives We evaluated the prognostic association of pT2 subclassification with the oncological outcomes in patients with prostate cancer (PCa) who underwent radical prostatectomy (RP) in South Korea. Patients and Methods We retrospectively reviewed 3,529 patients who underwent RP for pathologically organ-confined PCa between 2003 and 2017 at our center. We analyzed the differences in the rates of biochemical recurrence (BCR), overall survival (OS), and cancer-specific survival (CSS) between pT2 substages. Results According to the 2002 TNM staging system, 362 (15.3%) and 2,000 patients (84.5%) had T2a and T2c diseases. Four patients (0.2%) had T2b disease and none of them developed BCR. The mean follow-up period was 8.4±3.7 years and 175 patients (7.4%) had BCR. On multivariable analysis, pT2 subclassification (pT2a/b vs. T2c) was not a significant predictor of BCR (p=0.224) or OS (p=0.311). Biochemical disease-free survival (p=0.502), OS (p=0.091), and CSS (0.063) showed no significant difference between pT2 substages. Conclusion Our study revealed that the pT2 subclassification of PCa in Korean men provided no value for predicting BCR, OS, and CSS after RP, which agrees with recently reported results based on the updated 8th version of the AJCC TNM staging system. keywords : Prostate cancer, T2 subclassification, Biochemical recurrence