Trauma & Others(구연) (NP-033) 폐경 후 여성 생체 신공여자의 신 적출술 후 만성 신장질환 위험 예측 모델 ¹연세대학교 의과대학 비뇨의학교실 ²국립건강보험공단 일산병원 비뇨의학과 ³한양대학교 의과대학 비뇨의학교실 ⁴연세대학교 의과대학 외과학교실 이식외과 박지수¹, 윤민지¹, 나준채¹, 이형호², 윤영은³, 허규하⁴, 김명수⁴, 김순일⁴, 김유선⁴, 한웅규¹ Introduction: Menopause causes hormonal imbalance and results in several clinical signs. Few studies have been performed in regard to remnant kidney function and complications in living kidney donors after donor nephrectomy. However, there is no study in living kidney donors of postmenopausal women. This is the first study to develop prediction models of chronic kidney disease in living kidney donors of postmenopausal women after donor nephrectomy. Method: A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016 at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2. GFR was estimated with the use of the abbreviated Modification in Diet and Renal Disease Study equation. Patients with a previous CKD history or estimated GFR <60 mL/min/1.73 m2 were excluded. Among them, postmenopausal women aged 50 years and older with minimum follow up of 1 year were included. Result: Among 114 patients, 62 patients had developed a first-time onset of a CKD 3 level estimated GFR (GFR <60 mL/min/1.73 m2) by 1 year after surgery. The results of the multivariate analysis indicated that baseline preoperative hemoglobin, serum blood urea nitrogen (BUN), and serum creatinine were significantly higher in those with a CKD 3 level estimated GFR. Our logistic regression models derived from 3 variables predicted CKD with an area under the receiver operating characteristic curve of 0.710, an accuracy of 71.2%, and a sensitivity of 73.3%, and specificity of 68.6%. Conclusion: This study suggested the model that could assist with decision making about potential donors and for surveillance of those at risk of post-nephrectomy CKD in postmenopausal women. Although the underlying mechanisms regarding the effects of menopause on living kidney donors are unclear, further studies will be needed. keywords : donor nephrectomy; chronic kidney disease, postmenopausal women