Cancer - Kidney(구연) Oral Session 7 / Cancer - Kidney (Ⅰ) (O-076) Rm.201 10월 30일(수) 16:00-17:00 신세포암으로 근치적 신장 절제술을 받은 환자에서 반대쪽 정상 신장의 수술 전후 보상적 적응에 영향을 미치는 인자 성균관대학교 의과대학 비뇨기과학교실 유현수, 강민용, 성현환, 정병창, 서성일, 전성수, 이현무, 전황균 Purpose: We divided the renal compensatory process in patients treated with radical nephrectomy for renal cell carcinoma (RCC) into distinct preoperative and postoperative processes and identified the factors that affect each compensatory process. Materials and Methods: We retrospectively reviewed the records of 906 patients treated with radical nephrectomy for RCC. We defined the first compensatory process (process 1) as the compensatory adaptation of the contralateral normal kidney (CNK) from the point at which the RCC occurs to the point of nephrectomy. Furthermore, we defined the second compensatory process (process 2) as the compensatory adaptation of the CNK after nephrectomy. Therefore, total compensation was defined as the combination of these two processes. Multiple logistic regression analyses were used to identify significant factors associated with processes 1, 2, and total compensation. Results: The mean preoperative, and 1-week and 5-year postoperative glomerular filtration rate (GFR) was 84.5, 57.6 and 63.7 mL/min/1.73 m2, respectively. Female sex(p<0.001), lower body mass index (BMI)(p<0.001), no hypertension(p=0.019), lower preoperative GFR(p<0.001), larger tumor volume(p<0.001) and larger CNK volume(p<0.001) were significantly associated with process 1. Male sex(p=0.028), younger age(p=0.019), higher BMI(p<0.001), and no diabetes mellitus (DM)(p=0.033) were significant factors affecting process 2. Female sex(p<0.001), younger age(p<0.001), no DM(p=0.002), lower preoperative GFR(p<0.001), and larger tumor(p=0.001) and CNK volumes(p<0.001) were significantly correlated with total compensation. Conclusion: Different factors significantly affected each compensatory process. Process 1 was the more important process for the entire renal compensatory process. Therefore, factors that affect process 1 had a substantial role in the entire compensatory process. keywords : radical nephrectomy, contralateral normal kidney, compensatory adaptation