Basic Research - Neurourology & LUTS/BPH & Others(구연) Oral Session6 / Basic Research - non-Cancer (I): Neurourology (O-063) Rm.203 10월 30일(수) 15:00-16:00 복압성요실금 동물모델에서 지속적인 요도압력측정을 이용한 요자제반사와 요도압력의 상관관계 분석 대구 파티마병원 비뇨의학과¹, 피츠버그대학교 의과대학 약리학 및 세포생물학교실², 피츠버그대학교 의과대학 비뇨기과학교실³ 권준범¹, 윌리엄 디 그라웃², 요시무라 나오키³ This study evaluated the real-time changes in urethral pressure during the storage phase using a rat model with stress urinary incontinence (SUI) induced by simulated multiple birth traumas, and investigated the relationship between urethral continence function and dynamic parameters associated with the changes in urethral pressure. Sprague-Dawley rats were divided into sham and 3-times vaginal distension (VD) groups. After transection of T8-9 spinal cord, simultaneous bladder and urethral pressure recordings were performed during intravesical pressure elevation. Then, urodynamic parameters such as leak point pressure (LPP), urethral baseline pressure (UBP), maximum urethral pressure (MUP), the MUP-UBP differential (dUP) during intravesical pressure elevation, the bladder pressure when urethral contraction begins (Puc), and the bladder pressure at bladder neck opening (Pno) were measured and compared. Compared with sham group, LPP, UBP, dUP, MUP, Puc, and Pno were significantly decreased in VD group. The pressure differences between LPP and Pno (LPP-Pno), and between LPP and UBP (LPP-UBP) were also significantly different in two groups. However, the difference values of LPP and MUP (LPP-MUP) or Pno and UBP (Pno-UBP) were not altered after VD. Our new methods of simultaneous recordings of dynamic changes in bladder and urethral pressures are useful to fully evaluate the functional alterations in the urethral continence function in the SUI model induced by multiple VD. Moreover, LPP-UBP values, which corresponds to Valsalva LPP (VLPP)-maximum urethral closure pressure (MUCP) in clinical urodynamics, would be useful to evaluate the impaired urethral continence function after simulated birth traumas in animal models. keywords : Stress Urinary Incontinence, Urethral Pressure, Maximum Urethral Closure Pressure