Cancer - Bladder, Pelvis, Ureter & Others(구연) Oral Session 5 / Cancer - Bladder, Pelvis, Ureter & Others (Ⅰ) (O-052) Rm.201 10월 30일(수) 15:00-16:00 근치적 방광 전 절제술을 시행 받은 근육 침범 방광암에서 수술 전 신기능이 예후에 미치는 영향 울산대학교 의과대학, 서울아산병원 비뇨기과 임범진, 이원철, 경윤수, 유달산, 정인갑, 홍범식, 홍준혁, 안한종, 김청수 Introduction: To evaluate the impact of preoperative renal insufficiency on oncological outcomes in patients with urothelial carcinoma who underwent radical cystectomy. Materials and methods: Total of 898 patients with urothelial carcinoma who underwent radical cystectomy from January 2004 to December 2017 was retrospectively examined. All patients who underwent preoperative diethylene triamine penta-acetic acid renal scintigraphy were identified. We excluded distant metastasis. In total, 335 patients were included in the analysis. Patients were divided into the 2 groups according to GFR (group1: ≥90, group2: 60-89). Finally, 89 patients of GFR 1 group and 246 patients of GFR2 group were included in this study. We compared the clinico-pathological characteristics and oncological outcomes between two groups. Results: There was no difference in clinical stage and pathologic stage except age and GFR between the two groups. However, significant differences were noted in prognosis among the patients according to perioperative eGFR. Time to recurrence was 127.4 ± 7.7 months in GFR group1 arm versus 93.0 ± 4.9 months in GFR group2. (P = 0.011) Cancer specific survival was 133.5 ± 7.5 months in GFR group1 arm versus 106.0 ± 4.9 months in GFR group2. (P = 0.019) Overall survival was 127.4 ± 7.7 months in GFR group1 arm versus 93.0 ± 4.9 months in GFR group2. (P = 0.001). Conclusions: Patients with urothelial carcinoma with preoperative GFR < 90 ml/min/ 1.73 m2 had a significantly lower recurrence free survival, cancer specific survival and overall survival. keywords : Bladder cancer, Oncological outcome, Renal function