LUTS/BPH(구연) Oral Session4 / LUTS (Ⅰ) (O-038) Rm.203 10월 30일(수) 14:00-15:00 방광출구폐색 남성에서 nitric oxide와 요역동학 지표의 관계 가톨릭대학교 부천성모병원 조강준, 최진봉, 고준성, 김준철 Purpose: Nitric oxide system in the urothelium is one of the factors affecting bladder function. However, differences in the expressions of nitric oxide synthase (NOS) isoforms in the urothelium depending bladder function have not yet been clarified. We investigated the correlation between nitric oxide and urodynamic in men with bladder outlet obstruction (BOO) using analysis of NOS in the urothelium. Materials and Methods: We prospectively enrolled 25 men who planned to undergo surgical treatment for benign prostatic hyperplasia and identified as BOO in the preoperative urodynamic study. Bladder mucosal specimens were collected during surgical prostate resection. Expressions of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) in the urothelium were analyzed using immunofluorescence staining and enzyme-linked immunosorbent assay. The correlation of urodynamic parameters with expressions of eNOS, iNOS, and nNOS in all patients were assessed. We also compared the expressions of eNOS, iNOS, and nNOS between BOO with detrusor underactivity (DU) group and BOO without DU group. Results: In all patients the level of eNOS positively correlated with maximal flow rate (r=0.499, p=0.021) and with maximum bladder capacity (r=0.548, p=0.006). The level of iNOS positively correlated with maximum bladder capacity (r=0.483, p=0.017). In addition, the level of nNOS positively correlated with bladder contractility index (r=0.709, p =0.022) and with detrusor pressure at maximal flow (r=0.626, p=0.048) in all patients. The level of eNOS, iNOS, and nNOS did not significantly differ between BOO with DU group and BOO without DU group. Conclusions: This study suggests that NO was correlated with bladder function in men with BOO. In particular, nNOS may reflect the change in detrusor function. keywords : Nitric oxide synthase, urodynamics, bladder outlet obstruction