Basic Research - Neurourology & LUTS/BPH & Others(구연) Oral Session6 / Basic Research - non-Cancer (I): Neurourology (O-059) Rm.203 10월 30일(수) 15:00-16:00 The effects of bladder inhibition by fully implantable wireless tibial nerve stimulator in freely moving rats 성균관의대 삼성서울병원 ¹의공학연구센터, ²비뇨의학교실 박은경¹, 김태경¹, 김태우¹, 주재순¹, 임봉희², 이규성¹² OBJECTIVES The aim of this study was to investigate the effectiveness of frequent tibial nerve stimulation (TNS) using an implantable neurostimulator in unanesthetized rats. METHODES Fourty female Sprague-Dawley rats were used for stimulating tibial nerve in this study. We developed the tibial nerve stimulation system that consists of an implantable neurostimulator and a wireless power transmission to conduct a stable long-tern experiment. We needed to surgically insert the implantable stimulator in the tibial nerve. During saline infusion (0.8~1 ml/min), electrical stimulation (0.2 ms pulse width and 2 T intensity) was applied for 30 minutes in the tibial nerve while receiving power wirelessly. The cycle of stimulation continued as the post-stimulation effects diminished. We confirmed the bladder function effects for each stimulation frequency (10 Hz, 50 Hz). RESULTS We confirmed that the 10 Hz tibial nerve stimulation has the inhibitory effects and the 50Hz tibial nerve stimulation has the exciting effect of micturition reflex. Especially, repetitive stimulation significantly increased inter-contraction interval and bladder capacity (P<0.05) at 10 Hz. CONCLUSION The frequent and repetitive TNS protocol through tibial nerve stimulator is more effective for modulating micturition reflex than transient stimulation. Therefore, it is necessary to develop the implantable TNS device for more effective clinic therapy of overactive bladder. keywords : Tibial nerve stimulation, Overactive bladder, Implantable stimulator