Basic Research - Cancer(구연) Oral Session1 / Basic Research - Cancer (Ⅰ) (O-005) Rm.201 10월 30일(수) 13:00-14:00 Increased Expression Ratio of Urinary miR-H19 and miR-1913 to miR-3659: as a Non-Invasive Diagnostic Biomarker for Prostate Cancer 충북대학교 의과대학 비뇨의학교실 변영준, 박현미, 정필두, 이희윤, 서성필, 강호원, 김원태, 김용준, 윤석중, 이상철, 김원재 Background: MicroRNAs (miRNAs) are small non-coding RNA and are implicated as key regulator involving development, proliferation and pathogenesis of prostate cancer (CaP). Currently, it is believed that urinary miRNAs are promising new class of non-invasive biomarker for CaP since the stability of its. Here, we evaluated diagnostic performance of urinary hsv2-miR-H19 between CaP patients from benign prostate hyperplasia (BPH) controls. Mehods: Several candidate miRNAs were listed from urinary microarray data and tested by real-time polymerase chain reaction. For the current study, a total of 105 urine (58 CaP and 47 BPH) was performed to evaluate diagnostic potential of target miRNAs. Results: The expression ratio of urinary miR-H19 and miR-1913 to miR-3659 were up-regulated in CaP than in BPH controls (p <0.001). In addition, this ratio expression in urine could discriminate CaP from BPH with high sensitivity and specificity (p =0.002, 66.7% and 81.3%, respectively). Conclusions: Here, we demonstrated that increased expression ratio; urinary miR-H19 and miR-1913 to miR-3659 in CaP than in those of BPH controls. Our findings suggested that miR-H19+ miR-1913/ miR-3659 ratio expressions could be a relevant non-invasive diagnostic biomarker for CaP especially for those patients within PSA gray zone. keywords : Prostate Cancer, diagnosis, urine