Basic Research - Cancer(구연) Oral Session 3 / Basic Research - Cancer (Ⅱ) (O-029) Rm.201 10월 30일(수) 14:00-15:00 Down expression of collagen VI alpha 1 is associated with poor prognosis in bladder cancer 충북대학교 의과대학 비뇨의학교실 박현미, 변영준, 정필두, 이희윤, 서성필, 강호원, 김원태, 김용준, 윤석중, 이상철, 김원재 Collagen VI, a major extracellular matrix protein, is known to be associated with tumor growth and progression. It is highly expressed in various cancer types, however, that in bladder cancer (BC) exerted a diverse levels. In our previous study, the microarray and real-time PCR analysis demonstrated that collagen VI type alpha 1 (COL6A1) mRNA expression were lower in NMIBC as well as MIBC tissues when compared with controls (normal surrounding tissue of BC) (P<0.0001 each), and a significant difference was exerted between MIBC and NMIBC tissues (P<0.05). In NMIBC patients, lower COL6A1 mRNA expression was identified in patients with stage T1 than those with stage T0 (P<0.05). In MIBC patients, the expression levels of COL6A1 were lower in MIBC patients who with progression (P<0.05). The risk of progression in MIBC patients was 8.517 times higher (95% Confidence Interval, 2.070-35.039; P=0.029) if COL6A1 decreased. In conclusion, lower expression of COL6A1 correlates with BC prognosis, making it a useful marker for guiding treatment decisions. keywords : collagen VI type alpha 1, bladder cancer, progression