Cancer - Bladder, Pelvis, Ureter & Others(구연) Oral Session 5 / Cancer - Bladder, Pelvis, Ureter & Others (Ⅰ) (O-049) Rm.201 10월 30일(수) 15:00-16:00 진행성 방광암에서 근치적방광절제술 단독 치료의 결과 분석: 다기관연구 서울특별시립 보라매병원, 분당서울대학교병원, 고려대학교 안암병원, 성균관의대 삼성서울병원, 국립암센터, 울산대학교 서울아산병원, 서울대학교병원 유상준¹, 오종진², 강석호³, 정병창⁴, 서호경5, 홍범식6, 구자현7 Objectives: We assessed the predictors for survival in locally advanced bladder cancer in patients who underwent radical cystectomy without neoadjuvant chemotherapy using multicenter bladder cancer database. Materials and methods: From 1991 to 2017, a total number of 720 patients with locally advanced bladder cancer who treated with radical cystectomy at 6 university hospitals were included for the analysis. Kaplan-Meier analysis was performed for prediction of overall survival according to duration of survivorship. In addition, multivariable analysis was performed to determine the variables associated with overall. Median follow-up duration was 22 months. Results: Mean age at surgery was 65.7 years and body mass index was 23.4 kg/m2. Among 720 patients, male was 613 (85.1%) and female was 107 (14.9%). Pathologic T2 was observed in 284 (39.4%), T3 in 352 (48.9%), and T4 in 84 (11.7%) patients. Lymph node was involved in 333 (46.2%) patients. Median survival in these patients were 26.2 months. The 5-year overall survival was 30.9%, and increased to 32.7%. 42.0%, 59.8% in patients who survived ≥ 3 months, 12 and 24 months, respectively. In multivariable analysis older age, decreased body mass index, impaired performance status, decreased number of removed lymph nodes, advanced T or N stage, increased number of involved lymph nodes and the presence of lymphovascular invasion were determined as variables associated with decreased overall survival. Among these variables, decreased body mass index and performance status were not associated with overall survival in patients who survived ≥ 12 months after surgery. Conclusions: In patients with locally advanced bladder cancer, median survival after radical cystectomy without neoadjvuant chemotherapy was about 2 years. In addition to other clinical and pathologic factors, decreased body mass index is determined as a predictor for decreased overall survival in these patients by reducing the 3-months overall survival after radical cystectomy. keywords : Body mass index, Cystectomy, Survival, Urinary Bladder Neoplasms