Cancer - Prostate(구연) (NP-013) 만성 전립선염과 전립선암의 공존이 근치적 전립선 절제술 후 생화학적 재발에 미치는 영향 울산대학교 의과대학, 서울아산병원 비뇨의학과 이원철, 임범진, 경윤수, 유달산, 정인갑, 송채린, 홍범식, 홍준혁, 안한종, 김청수 Purpose : In some studies, chronic inflammation of prostate has adverse effect on oncological outcomes after radical prostatectomy. The aim of this study was to evaluate whether chronic inflammation on needle biopsy affects biochemical recurrence(BCR) in prostate cancer patients who underwent radical prostatectomy. Materials and methods : From February 2012 to October 2014, 312 patients who underwent radical prostatectomy were retrospectively reviewed. Patients were divided into two groups depending on the occurrence of BCR. Data of systemic prostate needle biopsy including quantity of chronic inflammation, clinical Gleason Score, number of total needle biopsy core, max percentage of positive core, positive core count were collected. Multiple logistic regression analysis was performed to find whether chronic inflammation was associated with biochemical recurrence. Results : There were 247(79%) patients in non-BCR group and 65(21%) patients in BCR group. Median age was 70.25 ± 6.73 and 68.11 ± 7.45 respectively.(p=0.027) Median PSA value was 8.60 ± 18.9 and 14.0 ± 15.73.(p=0.02) Median number of chronic inflammation on needle biopsy was 1.16 ± 1.84 in non-BCR group and 0.89 ± 1.70 in BCR group.(p=0.286) Median max percentage of tumor in the positive core was 35.33% ± 25.36 and 58.58 ± 28.95% respectively.(p<0.001) In the multiple logistic regression analysis, age, number of positive core, max percentage of positive core and surgical margin were significantly associated with occurrence of BCR. Conclusion : Chronic inflammation on prostate needle biopsy had no adverse effect on BCR. Age, number of positive core, max percentage of positive core and surgical margin were related with BCR. keywords : Chronic inflammation, Biochemical recurrence, Prostate cancer