Incontinence & Female Urology & Neurourology(구연) (NP-012) 최고요속 12ml/s 미만의 여성 환자에서 Tamsolusin 과 Bethanechol 병합요법의 효능 전남대학교병원 비뇨의학과. 송재익, 이호연, 김재현, 임도경, 김태희, 은성종, 오주용, 유성현, 김명수, 정호석, 유호송, 오경진, 김선옥, 정승일, 강택원, 권동득, 박광성 PURPOSE : Functional bladder outlet obstruction (BOO) is one of the most common disease caused voiding dysfunction in female. We assessed the effect of tamsulosin HCl (0.2 mg) with or without bethanechol (25 mg, TID) on female patients with a maximal flow rate (Qmax) less than 12 ml/s who were suspected of having functional bladder outlet obstruction (BOO). METHODS : Female patients with a Qmax less than 12 ml/s were selected for this study (n=379). The patients were treated with tamsulosin alone (0.2 mg/day; group I, n=312) or with tamsulosin combined with bethanechol (25 mg, TID; group II, n=67). Follow up evaluation for International Prostatic Symptom Score (IPSS) and uroflowmetric parameters of maximal flow rate (Qmax) and postvoiding residual urine (PVR) were performed before and 12 weeks after the initial treatment. RESULTS : Mean age of 379 patients was 67.3±17.6 years and mean duration of voiding symptom was 32.5±75.4 months. There was no statistically difference in baseline demographics between groups. After 12 weeks the treatment, total IPSS (Group I: from 21.27±6.88 to 16.67±7.85, Group II: from 26.4±10.5 to 22.3±12.1) and uroflowmetric parameters; Qmax (Group I : from 11.98±7.54 to 17.60±10.33, Group II: from 10.4±9.1 to 16.2±9.8); PVR (Group I: from 62.15±56.83 to 54.96±74.34, Group II: from 84.8±66.5 to 64.4±51.1) were statistically improved in both groups. However, there were no significant differences in subjective symptom scores or objective uroflowmetric parameters between the two groups, except for PVR (Group I: 7.19±66.83 Vs Group II: 20.4±58.5). CONCLUSIONS : Combination therapy with tamsulosin and bethanechol improved the subjective symptoms and uroflowmetric measures of female patients with a maximal flow rate of less than 12 ml/s. Women with a voiding dysfunction will not be benefitted by prescribing bethacholine agent, except for decreasing PVR. keywords : Functional bladder outlet obstruction, Female, Tamsulosin & Bethanechol