Cancer - Bladder, Pelvis, Ureter & Others(구연) (NP-006) 근치적 방광 전절제술을 시행한 방광암 환자들에서의 술 후 예후 예측인자로서 술 전 혈청 알부민/글로불린 비 경북대학교병원 비뇨의학과 교실 오정석, 이승윤, 박경민, 민경찬, 박동진, 하윤석, 이준녕, 권태균, 김태환 This study sought to if preoperative serum albumin/globulin ratio(AGR) could predict the prognosis in patients with in urothelial bladder cancer(UBC) after radical cystectomy(RC). A total of 183 patients with UBC who underwent RC in tertiary hospital between 2008 and 2019 were retrospectively analyzed. The AGR was calculated as follows: albumin/(total protein-albumin). The AGR was devided into 2 groups for receiver operating characteristics curve (ROC) analysis. Survival was estimated using Kaplan-Meier analysis and compared the log rank test. Cox proportional hazards models were used for multivariate survival analysis. The best cut-off AGR value was set at 1.34 according to the ROC curve for the prediction of metastasis. The area under the curve AUC of the AGR was 0.687(95%CI: 0.598–0.778, P < 0.001). Patients who had a lower pretreatment AGR(<1.34) were identified as the low AGR group, and the group contained 72 patients(38.9%). The remaining 111 patients(61.1%) were identified as the high AGR group. Compared to patients with high AGR group, those in low AGR group had more advanced stage tumors. Kaplan-Meier curves revealed that patients in low AGR group had a significantly lower rate of metastasis-free survival(MFS). Furthermore, a lower rate of cancer-specific survival(CSS) was exhibited amongst patients in low AGR group. Multivariable Cox regression analysis showed that preoperative AGR was an independent prognostic factor for MFS and CSS. A decreased AGR, which is an easily accessible and cheap marker to use, was a worse prognostic effect on MFS and CSS in patients keywords : Radical cystectomy, Albumin/globulin ratio, Urothelial bladder cancer