Cancer - Prostate(구연) International Session I (I-08) Rm. 202 10월 31일(목) 15:00-16:00 Multiple primary cancers in men with sporadic or familial prostate cancer: its clinical implications 분당서울대학교병원 비뇨기과학교실 김명, 김진혁, 김정권, 이학민, 오종진, 이상철, 홍성규, 이상은, 변석수 Purpose: To investigate the prevalence of multiple primary cancers in patients with prostate cancer (PCa) and its association with a family history of PCa. Materials and methods: We examined 1,102 patients with PCa having prospectively acquired pedigrees and analyzed information regarding multiple primary cancers. The prevalence of concordant cancers was assessed with respect to family history of PCa. Odds ratios for each concordant cancer in men with first-degree familial PCa were estimated. Clinical characteristics were compared between men with and without concordant cancers. Results: The prevalence of multiple primary cancers in sporadic PCa was 12.0%, similar to that of familial (11.8%, p=0.963) and first-degree familial (13.5%, p=0.698) disease. Gastrointestinal cancer was the most common concordant cancer (3.6%), followed by colorectal (2.9%), lung (1.5%), urothelial (1.3%), kidney (1.1%), and other cancers. Colorectal cancer was more frequent in first-degree familial PCa than in sporadic disease (6.8 vs. 2.7%, p=0.045). However, the rates of other concordant cancers were similar between the two groups (p range, 0.242–0.963). Compared with sporadic disease, the age-adjusted odds ratio for concordant colorectal cancer in first-degree familial PCa was 2.930 (95% confidence interval, 1.082–7.929). Patients with concordant colorectal cancer had fewer (2.8 vs. 3.9 cores, p=0.041) and a lower percentage of (23.5 vs. 33.1%, p=0.030) positive biopsy cores than PCa only patients. Conclusions: A family history of PCa was significantly associated with a risk of concordant colorectal cancer. These findings imply that some PCa shares a genetic pathogenesis with colorectal cancer. keywords : Prostate cancer; Familial; Multiple primary cancer; Clinical characteristics