Cancer - Kidney(구연) Oral Session 7 / Cancer - Kidney (Ⅰ) (O-070) Rm.201 10월 30일(수) 16:00-17:00 신장 부분 절제술 이후 동측 신기능의 장기간 추적 관찰 울산대학교 서울아산병원 비뇨의학고 교실¹, , 한림대학교 동탄성심병원 비뇨의학과 교실², 한림대학교 성심병원 이동현, 김종근, 유달산, 정인갑, 홍범식, 홍준혁, 김청수, 안한종, 송채린 Introduction There has been a debate whether the long-term ipsilateral renal function after partial nephrectomy (PN) is affected by preserved renal parenchymal volume or ischemic insult during the surgery. Materials and methods We analyzed the data from 530 patients who received PN. Separated renal functions were measured preoperatively and followed postoperatively at 3 months and annually thereafter using DTPA GFR scan. Perioperative variables affecting the long-term ipsilateral GFR were assessed by a linear mixed model. Results The mean preoperative ipsilateral GFR was 43.4 ml/min which decreased by 26.7% at postoperative 3months, whereas 15.2% reduction of normal renal parenchymal volume was noted on CT scan. The ipsilateral renal function GFR gradually recovered thereafter until postoperative 4 years. (percentage of GFR reduction after 1, 2, 3, 4 and 5 years after operation; 22.3%, 18.5%, 14.7 %, 10.0 % and 9.6%). Using linear mixed model, loss of ipsilateral kidney volume, preoperative ipsilateral GFR, complexity of tumor and ischemia time were affected to long-term recovery of ipsilateral GFR after PN. The ipsilateral renal function almost completely recovered except for the renal function reduction due to loss of parenchymal volume at 2 years after operation. Conclusion Loss of ipsilateral kidney volume was a major determinant of preserved renal function after PN, in the early postoperative period and at long-term follow-up. GFR reduction due to other factors may recovered until the fourth year after PN. keywords : Kidney neoplasms, Glomerular filtration rate, Ischemia time