Cancer - Kidney(구연) Oral Session 7 / Cancer - Kidney (Ⅰ) (O-067) Rm.201 10월 30일(수) 16:00-17:00 비전이성 신세포암으로 신적출술을 시행받은 환자에 있어 빈혈과 저알부민혈증의 예후인자로서의 가치 ¹대진의료재단 분당제생병원, 아주대학교병원 조대성¹, 김선일, 김세중 Purpose: The aim of this study was to evaluate the impact of anemia and hypoalbuminemia on recurrence and survival in patients with non-metastatic renal cell carcinoma (RCC) treated with radical or partial nephrectomy. Materials and Methods: Between June 1994 and January 2017, 482 patients with RCC underwent radical or partial nephrectomy at two hospitals. Among these patients, 21 patients with lymph node or distant metastasis were excluded. Thus, the medical records of the remaining 461 patients (307 men and 154 women, mean age of 55.9 years) were retrospectively reviewed. The median follow-up duration was 71 months (range 4 to 272 months). The prognostic significance of various clinicopathological variables including anemia and hypoalbuminemia was analyzed using univariate and multivariate analysis. Results: Of the total 482 patients, 132 patients (28.6%) had anemia, and 36 patients (7.8%) had hypoalbuminemia. Forty-eight patients (10.4%) developed local recurrence or distant metastasis and 26 patients (5.6%) died of disease during the follow-up period. In the univariate analysis, anemia, hypoalbuminemia, tumor size, T stage, Fuhrman’s nuclear grade, coagulative tumor necrosis, and lymphovascular invasion were significant predictors of recurrence-free survival. Also, anemia, hypoalbuminemia, tumor size, T stage, Fuhrman’s nuclear grade, and lymphovascular invasion were significant predictors of cancer-specific survival. In the multivariate analysis, hypoalbuminemia (p<0.001), tumor size (p=0.002), T stage (p<0.001), Fuhrman’s nuclear grade (p=0.025), and lymphovascular invasion (p=0.039) were independent predictors of recurrence-free survival. Also, anemia (p=0.023), hypoalbuminemia (p=0.030), tumor size (p=0.001), and T stage (p=0.001) were independent predictors of cancer-specific survival. Conclusions: Our results suggest that hypoalbuminemia is independent prognostic factor for recurrence-free survival and hypoalbuminemia is independent prognostic factor for recurrence-free and cancer-specific survival in patients with non-metastatic RCC treated with radical or partial nephrectomy. These findings indicate that anemia and hypoalbuminemia could be an effective tool for predicting recurrence or survival in patients undergoing nephrectomy for non-metastatic RCC. keywords : Renal cell carcinoma, anemia, hypoalbuminemia