Basic Research - Cancer(구연) (E-012) 전립선암 발현에 있어서 Estrogen receptor α (ERα), Estrogen receptor β (ERβ), Androgen receptor (AR), SIRT1, SIRT2, SIRT3 의 역할 경상대학교병원¹, 창원경상대학교병원² 최재휘¹, 이신우¹, 제성욱¹, 최세민¹, 현재석¹, 이민호², 이천우², 감성철², 화정석¹ Objectives The purpose of this study is to find out the effects of Estrogen receptor α (ERα), Estrogen receptor β (ERβ), AR (AR), SIRT1, SIRT2 and SIRT3 on the expression of prostate cancer Material and methods From October 2010 to January 2015, a study was conducted on 70 patients who underwent radical prostatectomy after prostate cancer (PCa) diagnosis. We are collect clinical information such as Age, hypertension (HTN), diabetes (DM), body mass index (BMI), TPSA level, Testosterone level, Gleason score, transrectal prostate sonography, Prostate MRI, and Bone scan were collected. This information ware retrospectively and analyzed. Normal tissue and prostate cancer tissues were separated using the stored Prostate paraffin tissue block, and expression patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in each tissue were analyzed through immunochemical staining. Results In the case of ERα, ERβ, and AR, the expression patterns between normal prostate tissue (NPT) and PCa tissues (PCAT) in ERβ showed negative expression in 61 (87.1%) of NPT and 9 (12.9%) of PCAT. And ERβ showed Positive expression in 9 (12.9%) of NPT and 50 (71.4%) of PCAT. There was a statistically significant difference (P = 0.000). AR showed negative expression in 47 (67.1%) of NPT and 14 (20.0.9%) of PCAT. And AR showed Positive expression in 23 (32.9%) of NPT and 56 (80.0%) of PCAT. There was a statistically significant difference (P = 0.000). In ERα, no significant difference was found in the expression pattern between cancer tissue and normal tissue. SIRT2 was positively expressed in 60 (85.7%) patients in NPT and 43 (61.4%)in PCAT. And negatively expressed 10 (14.3%) in NPT and 27 (36.6%) in PCAT. There was a statistically significant difference (P = 0.001). In SIRT1 and SIRT3, there was no statistically significant difference in the expression pattern. In addition, in this study, univariate and multivariate analysis was performed to identify factors affecting the expression of PCa among various factors of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3. (Table 3) At the result AR [OR; 27.928 (16.857 – 199.061)] (P = 0.0000) as a risk factor for PCa expression. Conclusion As a result of the study, AR was identified as a risk factor for PC expression, and SIRT2 factor was identified as a factor that lowers PCa expression. Further research on this should be continued. keywords : SIRT, prostate cancer, androgen receptor