Endourology & Stone Disease(구연) (E-158)

Obesity, metabolic health, and urolithiasis in adults: a nationwide population-based study
한림대학교 의과대학 비뇨의학교실, 한림대학교 동탄성심병원
권효상, 최창일, 김종근, 김의석, 이성호, 한준현
Objective: To investigate the risk of symptomatic urinary stone disease requiring surgical treatment according to obesity and metabolic health status using a nationwide dataset of the Korean population.

Patients and Methods: Of the 5,300,646 persons who underwent health examinations between the year 2009 and 2016, within one year after the health examination, 35,137 patients who underwent surgical treatment for urolithiasis were enrolled. Participants were classified as “obese” (O) or “non-obese” (NO) using a BMI cut-off of 25 kg/m2. People who developed ≥1 metabolic disease component (hypertension, diabetes, dyslipidemia) in the index year were considered “metabolically unhealthy” (MU), while those with none were considered “metabolically healthy” (MH).

Results: Out of 34,330 participants excluding 843 missing, 16,509 (48.1%), 4,320 (12.6%), 6,456 (18.8%) and 7,045 (20.5%) subjects were classified into the MHNO, MUNO, MHO, and MUO group, respectively. Mean BMI was 22.1 ± 1.9kg/m2, 22.9 ± 1.6kg/m2, 26.9 ± 1.8kg/m2, and 27.9 ± 2.4 kg/m2 respectively. After adjusting the age and gender, the subjects in the MUNO group had an HR (95% CI) of 1.192 (1.12, 1.268), those in the MHO group, 1.242 (1.183, 1.305) and those in the MUO group, 1.341 (1.278, 1.407) for either ESWL or Surgery, compared to those in the MHNO group.

Conclusions: Metabolically healthy, obese individuals have a higher risk of developing symptomatic urolithiasis than non-obese, unhealthy, but have a lower risk than obese, unhealthy. It suggests that metabolic health and obesity have collaborative effects, independently affecting the development of symptomatic urinary stone diseases.
keywords : Obesity, Diabetes Mellitus, Urolithiasis

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