Cancer - Kidney(구연) (E-080) 만성 신부전 환자에서 작은 신종물에 대한 치료로 부분 신 절제술과 고주파 열 치료술 간 비교 성균관대학교 의과대학 비뇨기과학교실 유현수, 강민용, 성현환, 전황균, 정병창, 전성수, 이현무, 서성일 Objectives We compared functional and oncologic outcomes between partial nephrectomy (PN) and radiofrequency ablation (RFA) for small renal masses (≤4cm) in chronic kidney disease (CKD) patients to decide optimal treatment in those patients. Materials and Methods We identified CKD patients treated with PN or RFA for small renal mass between 2005 and 2019. A total of 1332 patients were included. After patients were stratified by 2 category according to CKD stage (CKD stage 2, CKD stage 3 or high), oncologic outcomes including recur-free survival (RFS), cancer-specific survival (CSS) overall survival (OS) and renal functional outcomes were compared between PN and RFA groups. Also, RFS and renal functional outcomes for RFA group was analyzed according to anesthesia method. Results Among 1332 patients, 1195 patients were CKD stage 2 and 137 patients were CKD stage 3 or high. Among patients with CKD stage 2, the 5-year RFS, CSS and OS were significantly higher in PN group (p<0.001, p=0.004, p<0.001, respectively). The mean percentage change of eGFR at post-treatment 1 year was not significantly different between groups (p = 0.458). Among patients with CKD stage 3 or high, the 5-year RFS and OS were significantly higher in PN group (p=0.001, p=0.004, respectively). But regarding CSS, there was no significant difference between groups (p=0.939). The mean percentage change of eGFR at post-treatment 1 year was not significantly different between groups (p = 0.132). Among patients treated with RFA, RFS was higher and renal functional decline was lower in the general anesthesia group than local anesthesia, although the difference was statistically insignificant. Conclusion PN provides a higher RFS rate than RFA in CKD patients with small renal tumor. However, patients with small renal tumor rarely dies of renal cancer. RFA could be recommended as a good choice in patients who are poor candidates for surgery, due to CKD. keywords : Partial nephrectomy, Radiofrequency ablation, Chronic kidney disease