Cancer - Prostate(구연) (E-124)

거세저항성전립선암 환자에서 전산화단층촬영 영상을 통하여 취득한 근육 특성의 예후인자로써의 의미
연세의대 신촌세브란스병원 비뇨의학교실¹
연세의대 강남세브란스병원 비뇨의학교실²
이종수, 김병선, 박지수, 허지은, 안현규, 장원식, 함원식, 나군호, 최영득
Limited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on castration-resistant prostate cancer (CRPC) outcomes. Skeletal muscle index (SMI) and skeletal muscle attenuation (SMA) were measured for 411 patients at the L3 vertebral level using computed tomography at CRPC diagnosis and were dived to low and high groups at the value of median. Analysis of the skeletal phenotypes and age (<70 and >70 years) was performed to evaluate the effect of SMI and SMA. The median survival rates for patients with low and high SMI were 19 and 24 months (p = 0.015), and those with low and high SMAs were 15 and 26 months (p < 0.001), respectively. In the subgroup analysis by age, SMA was a significant prognosticator in both groups, while SMI was a significant prognosticator only in patients aged >70 years. Patients with low SMA + low SMI had the worst prognosis. Muscle characteristics seems to be a prognosticator in survival of CRPC patients and may be considered in treatment planning.
keywords : castration-resistant prostate cancer; body composition; computed tomography

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