Cancer - Prostate(구연) (E-128)

국소 전립선 암 환자에서 수술과 방사선 치료 후 우울증 혹은 정신과적 질환의 발생의 차이가 있는가?
고려대학교 안산병원 비뇨의학과
태범식, 전병조, 이영훈, 유정완, 한재현, 최훈, 배재현, 박재영
Purpose: Previous studies suggested that cancer patients are known to have a high risk of depression. However, there are few studies on the difference in the incidence of depression or psychological disorder among patients with prostate cancer according to radiation treatment (RTx) and surgical treatment.
Materials and Methods: Using information from the National Health Insurance Sharing Service database with regard to the entire Korean adult PC population (n = 210,924) between 2007 and 2017 were analyzed. Adjusted hazard ratio of depression or psychological disorder associated with the treatment were estimated using propensity score–matched Cox proportional hazards models and Kaplan-Meier survival analyses.
Results: Our final cohort comprised of 9,456 individuals with PC, including 8,050 men who underwent operation. During the mean follow-up of 7.1 years, 968 patients were newly diagnosed with psychological disorder, 592 patients were newly diagnosed with depression and 17 patients committed suicide. In the unmatched cohort, there was significant difference in baseline characteristics in age, and comorbidities between operation and RTx group. The adjusted hazard ratio for psychological disorder for operation group was 1.024 (95% CI: 0.819–1.280, P = 0.838) compared with RTx and depression for operation group was 0.843(95% CI: 0.641-1.108, p=0.221).
Conclusion: In this nationwide, population-based study, there were no difference between operation and RTx treatment group in risk of depression or psychological disorder.
keywords : Prostate cancer, depression, Treatment