Trauma & Others(구연) (E-231) Lidocaine 방출 카테터를 이용하여 카테터로 유도된 방광 통증 경감 ¹한양대학교 의과대학 비뇨기과학교실, ²한양대학교 의생명공학전문대학원 임상의과학과, ³서울대학교 공과대학 바이오 엔지니어링전공, ⁴서울대학교 공과대학 바이오 엔지니어링전공, 5 서울대학교 의과대학 의공학과 , 6 서울대학교 의용생체공학연구소 장은비*¹,², 김초림³, 홍성휘¹, 윤영은¹, 최영빈4, 5, 6, 이지영¹, 황현지¹,², 문홍상¹ Purpose The urethral catheter is used for urine drainage, but side effects pain, frequency, urgency, and inflammation can occur. Therefore, our team has developed a lidocaine-eluting catheter (LRC) that reduces discomfort caused by catheters and verified its efficacy. Methods LRC was developed and it identified whether that reduces bladder sensitivity in rats by cystometry. The animal group is divided into cyclophosphamide (CYP) treated group (IC bladder group) and a normal bladder group, and CYP was used as a drug to induce cystitis. Each group consists of 5 rats without a catheter in the bladder, 5 rats with a 1cm silicone catheter, a group with a 1cm PLGA (Poly Lactic-co-Glycolic Acid, without lidocaine) coated catheter, and a group with a 1cm lidocaine catheter. After measuring cystometry, inflammation and pain markers such as IL-6, COX-2, and NGF were measured in bladder tissue by Immunohistochemistry (IHC), RT-PCR (Quantitative Reverse Transcription Polymerase Chain Reaction) and ELISA (Enzyme-linked immunosorbent assay). Results LRC showed continuous release of lidocaine for 7 days in PBS via HPLC. In the LRC group compared with the normal catheter group, the bladder pressure was decreased and the bladder contraction interval was increased. Expressions of IL-6, COX-2, and NGF were decreased in the LRC group than in other groups. Conclusion Taken together, we verified that the lidocaine-eluting catheter reduced the sensitivity, pain, and inflammation of the bladder. Therefore, we expect that the LRC reduce catheter-related pain or discomfort. keywords : Lidocaine, Bladder pain, Cystometry