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여성에서 과민성방광 약물 처방율의 계절별 변화 |
| 연세의대 강남세브란스병원 비뇨의학과, ¹한미약품 데이터사이언스팀 |
| 김종원, 안현규, 고종철, 이돈구, 하지수, 김재환¹, 박소정¹, 조강수 |
Cold season aggravates lower urinary tract symptoms, especially overactive bladder (OAB) symptoms. This aspect was studied mainly in men, but rarely in women. We investigated whether cold season influences OAB-drug prescription rate (OAB-DPR) in women.
Women aged >18 years were selected from the Korean Health Insurance Review and Assessment Service-National Patient Sample data between 2012 and 2016. OAB-DPR was calculated according to age and seasonal groups. The prescription rates in summer (June, July, and August) and winter (January, February, and December) were compared. Sub-analysis was performed by age group.
In total, 3,061,343 adult women were included. Overall OAB-DPR was 3.75% (114,940/3,061,343). Overall OAB-DPR in summer and winter were 1.41% (43,090/3,061,343) and 1.54% (47,038/3,061,343), respectively (p<0.001). However, the seasonal variation differed by age group (p<0.001). OAB-DPR was significantly lower in winter than in summer in women aged <50 years (odds ratio 0.942; 95% confidence interval, 0.918–0.967; p<0.001), but was significantly higher in winter than in summer in women aged ≥50 years (odds ratio 1.153; 95% confidence interval, 1.135–1.171; p<0.001)(Fig.1).
In conclusion, OAB-DPR in women was significantly influenced by seasons; its seasonal variations differed with age. OAB-DPR was higher in summer in women aged <50 years, however it was higher in winter in those aged ≥50 years. Our findings suggest that female hormonal status may be involved in the contradictory effect of seasons on OAB symptoms.
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keywords : Seasons, Overactive bladder, Women |
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