Cancer - Prostate(구연) (E-134)

전립선암 환자에서 고강도집속초음파치료를 시행할때 시행방법에 따른 결과의 비교.
한림대학교 강남성싱병원 비뇨기과학교실¹
서울대학교 의과대학 비뇨기과학교실²
김학주², 권오승¹, 이학민², 변석수², 홍성규²
Introduction: As the ablation mechanism has some theoretical possibility for missing or skipped lesion, some clinicians apply high-intensity focused ultrasound (HIFU) as double ablation. Therefore we analyzed post-procedure complications and clinical outcomes between single and double ablation during HIFU in prostate cancer (PCa) patients.

Materials and Methods: The data of 99 patients who had HIFU procedure for localized PCa were analyzed. All the patients had unilateral disease and HIFU was performed as hemi-gland ablations. The patients were categorized into two subgroups (single versus double ablation group) and postoperative complications and functional outcomes were compared between two subgroups after HIFU.

Results: The rate of decrease in the level of prostate specific antigen did not differ between two groups. Furthermore, we could not find any significant differences in early postoperative complications (p=0.410). In addition, the voiding symptom scores after HIFU were not significantly different between the two groups at postoperative 1-, 3-, 6-month. However, single ablation group had significantly shorter hospital stay than the double ablation group (2.4±1.1 vs 3.1±1.3, p=0.007).

Conclusions: The double ablation did not increase intraoperative and postoperative complications in our initial experience in HIFU. Moreover, there were no clinical evidences showing that the double ablation technique cause more discomforts after HIFU. However, our study did not analyze the oncological outcomes except the level of prostate specific antigen with very short-term follow-up periods and needed further investigation with follow-up biopsy outcomes to verify if the double ablation can have superior oncological outcomes than single ablation.
keywords : prostate cancer, HIFU